Hi Eric. I have had same issues. It appears that there is a problem with the audio track which slows down playback on timeline.
Slow playback only occurred for me when I dragged sequence onto the new item tab to create a new sequence for multi cam editing. There would be a 3 sec delay or longer between pressing the space bar and the video playing.
This makes editing very frustrating.
Here is how I overcame the problem.
1. First copy all the audio tracks from sequence.
2. Drag sequence onto the new item tab to create a new nested sequence.
3. Delete the audio track in the new sequence, now paste in the copied audio from the original sequence to the new nested sequence, you now have a new sequence with the original audio track in it.
now press play and video and audio will play smoothly.
Hope this helps